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Therefore, inflammation must be well regulated in these early stages.Several studies have demonstrated that the main mechanisms involved in the inflammatory reaction are closely associated with the generation of free radicals and the creation of oxidative stress.These results may confirm the interesting potential of this plant as a treatment of various inflammatory and pain diseases.Inflammatory reaction is one of the most important defense mechanisms against tissue injury caused by physical and chemical agents, noxious stimuli, heat, antigen-antibody reaction, and microbial effect.Currently, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed because of their efficacy in the management of pain, inflammation, and rheumatic disorders.However, their long-term therapeutic use is often associated with adverse effects such as gastrointestinal ulcers and renal insufficiency [5]. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site.Detailed information on how Wiley uses cookies can be found in our Privacy Policy.

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Thus, free radicals are important mediators that provoke or sustain inflammatory processes, and consequently, cells and tissues require antioxidant enzymes, including superoxide dismutase, catalase, and glutathione peroxidase to neutralize and decompose these reactive oxygen species [2, 4].

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These molecules include alkaloids, phenolic acids, tannins, and flavonoids which possess interesting biological activities like anti-inflammatory, anticarcinogenic, antimicrobial, and antioxidant.

Euphorbia is the largest genus of the family Euphorbiaceae and comprises about 1000 species.

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